Cytokines, immune system and immunotherapy
We are interested in the function of cytokines in the immune system during health and disease. We study how cytokines coordinate immune homeostasis and responses, and how they stimulate various immune cells in vitro and in different models of cancer, inflammatory and autoimmune disease, as well as allograft rejection. We generate and characterize natural versus modified cytokine formulations, including cytokine-antibody complexes, in order to better understand cytokine biology and improve cytokine-directed immunotherapy.
Cytokine immunotherapy
Cytokines, especially those sharing the common gamma chain cytokine receptor such as IL-2, play a central role in the immune system.
Monoclonal antibody (mAb) complexes
By combining IL-2 with anti-IL-2 mAb to specific complexes, the immune system can be skewed to combat cancers and autoimmune diseases.
Therapeutic use of cytokines
Cytokines and particularly cytokine/mAb complexes can be used for immunotherapy in cancer, inflammatory or autoimmune diseases.
Our team consists of PhDs, MDs and MD-PhDs interested in different aspects of immunology.
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Candidates interested in joining our laboratory should apply via e-mail. PhD candidates will need to be accepted to the Life Science Zurich Graduate School program and pursue one of the following tracks: Cancer Biology or Microbiology and Immunology.
